کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5269659 | 1385395 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Polyketides from the mangrove-derived endophytic fungus Acremonium strictum Polyketides from the mangrove-derived endophytic fungus Acremonium strictum](/preview/png/5269659.png)
Five new polyketide derivatives, 6â²-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6-12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhizophora apiculata. The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6, 7, and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC50 values 27.1, 76.2, and 8.3 μM, respectively) and resistant A2780 cell lines (IC50 values 12.6, 30.1, and 19.0 μM, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3 μM).
Journal: Tetrahedron Letters - Volume 55, Issue 24, 11 June 2014, Pages 3463-3468