Organocatalysis in aqueous micellar medium: a new protocol for the synthesis of [1,2,4]-triazolyl-thiazolidinones

- Environmentally friendly methodology for the synthesis of triazolyl-thiazolidinones.
- Methodology uses CTAB as a surfactant and acetic acid as an organocatalyst.
- Methodology involves use of micellar catalysis to obtain the desired products.
- Use of CTAB at 60 °C gave the best results.
- These triazolyl-thiazolidinones are thought to possess important biological properties.

A new environmentally friendly methodology for the efficient synthesis of biologically significant triazole thiazolidinone hybrids in aqueous medium, using acetic acid as an organocatalyst in the presence of cetyltrimethylammonium bromide (CTAB) surfactant has been developed for the first time. The effect of several surfactants on the yield and completion time of the reaction was investigated and it was found that the use of CTAB at 60 °C gave the best results (79-96% in 20 min-35 min) for the synthesis of the target compounds.