کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5269858 1385400 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An environmentally-friendly one-pot synthesis of 4-sulfonyl benzoic acids
ترجمه فارسی عنوان
یک سنتز یک گلدان یکنواخت 4-سولفونیل بنزوئیک
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

This Letter reports an environmentally-friendly one-pot SNAr reaction of thiols to 4-halobenzoic acid methyl esters to provide 4-substituted sulfone benzoic acids and picolinic acids after bleach-mediated oxidative workup. These acid intermediates were synthesized on gram scale, are perfect partners for library synthesis, and have good physical chemical properties useful for drug discovery.

This Letter reports the first environmentally-friendly one-pot SNAr reaction of thiols to 4-halobenzoic acid methyl esters to provide 4-substituted sulfone benzoic acids and picolinic acids after oxidative workup. These acid intermediates were performed on gram scale and are perfect partners for library synthesis and have good physical and chemical properties for drug discovery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 22, 28 May 2014, Pages 3295-3298
نویسندگان
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