Palladium-catalyzed asymmetric hydrogenation of simple ketones activated by Brønsted acids

Homogeneous Pd(OCOCF3)2/(R)-C4-TunePhos has been successfully applied in the asymmetric hydrogenation of simple ketones activated by catalytic amount of Brønsted acid with up to 88% ee.

Homogeneous Pd(OCOCF3)2/(R)-C4-TunePhos has been successfully applied in the asymmetric hydrogenation of unfunctionalized ketones activated by catalytic amount of Brønsted acid with up to 88% ee.