A facile synthesis of (Z)-5-(substituted)-2-(methylthio)thiazol-4(5H)-one using microwave irradiation and conventional method

- Synthesis of important drug molecules with a Rhodanine moiety by MW irradiation as well as conventional method.
- We have successfully developed an easy access to a new series of (Z)-5-(substituted)-2-(methylthio)thiazol-4(5H)-one.
- Developed the mild reaction conditions, well to excellent yields, easy workup.

A new effective approach to the synthesis of some new (Z)-5-(substituted)-2-thioxothiazolidin-4-one 3a-l and (Z)-5-(substituted)-2-(methylthio)thiazol-4(5H)-one 5a-l is reported under microwave irradiation as well as conventional conditions.