کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5271222 | 1385435 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Three structurally interesting new diterpenoids, phyllanflexoids A-C (1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1-3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5 μM, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4670-4674
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4670-4674
نویسندگان
Jian-Qiang Zhao, Jun-Jiang Lv, Yan-Ming Wang, Min Xu, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Yi-Fei Wang, Ying-Jun Zhang,