کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5271254 | 1385435 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and charge transferability of DNA possessing a naphthalimide photosensitizer at an extrahelical position
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
DNA oligonucleotides possessing naphthalimide (NI) at the C5 position of deoxyuridine through an ethynyl-containing linker have been synthesized. Based on time-resolved laser flash photolysis, we showed that the photo-induced charge transfer occurs between NI at the C-5 position and the guanine base of DNA with almost same efficiency (1.8%) when compared to the terminal NI-modified DNA (2.3%). Photoelectrochemical experiments showed that DNA with NI immobilized on the gold electrode generated the photocurrent (28 ± 2 nA/cm2). These results revealed that the NI chromophore located in the extrahelical position could work as a good photosensitizer to induce the charge transfer in DNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4796-4799
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4796-4799
نویسندگان
Tadao Takada, Yuta Kawano, Akane Ashida, Mitsunobu Nakamura, Kiyohiko Kawai, Tetsuro Majima, Kazushige Yamana,