کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5271254 1385435 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and charge transferability of DNA possessing a naphthalimide photosensitizer at an extrahelical position
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and charge transferability of DNA possessing a naphthalimide photosensitizer at an extrahelical position
چکیده انگلیسی

DNA oligonucleotides possessing naphthalimide (NI) at the C5 position of deoxyuridine through an ethynyl-containing linker have been synthesized. Based on time-resolved laser flash photolysis, we showed that the photo-induced charge transfer occurs between NI at the C-5 position and the guanine base of DNA with almost same efficiency (1.8%) when compared to the terminal NI-modified DNA (2.3%). Photoelectrochemical experiments showed that DNA with NI immobilized on the gold electrode generated the photocurrent (28 ± 2 nA/cm2). These results revealed that the NI chromophore located in the extrahelical position could work as a good photosensitizer to induce the charge transfer in DNA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 35, 28 August 2013, Pages 4796-4799
نویسندگان
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