کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5271985 | 1385454 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Highly efficient one-pot, three-component Mannich reaction catalysed by boric acid and glycerol in water with major 'syn' diastereoselectivity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Boric acid and glycerol efficiently catalysed the one-pot, three-component Mannich reaction of aldehydes, aromatic amines and cyclic ketones in water at ambient temperature to afford the corresponding β-amino carbonyl compounds in good yields. All but one reaction proceeded with moderate 'syn' diastereoselectivity. This observation is just the reverse of the major anti diastereoselectivity obtained in most of the earlier reported procedures. The methodology is mild and efficient using minute quantities of catalyst with no side products and a very simple work-up procedure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 50, Issue 29, 22 July 2009, Pages 4246-4250
Journal: Tetrahedron Letters - Volume 50, Issue 29, 22 July 2009, Pages 4246-4250
نویسندگان
Chhanda Mukhopadhyay, Arup Datta, Ray J. Butcher,