کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5272123 1385458 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A photolabile protection strategy for terminal alkynes
ترجمه فارسی عنوان
یک استراتژی حفاظت از عکس برای آلکینهای ترمینال
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

We present a strategy for photolabile protection of terminal alkynes. Several photo-caged alcohols were synthesized via mild copper(II)-catalyzed substitution between tertiary propargylic alcohols and 2-nitrobenzyl alcohol to build up robust, base stable o-nitrobenzyl (NB) photo-cleavable compounds. We compare the new photolabile protecting group with the commonly used alkyne protecting group, 2-methyl-3-butyn-2-ol and the results show that NB ethers are stable under the cleaving conditions for the cleavage of methylbutynol protected alkynes. Additionally, we present the synthesis of photo-cleavable NB derivatives containing thiol groups that can serve as agents for photoinduced surface functionalization reactions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 54, Issue 40, 2 October 2013, Pages 5426-5429
نویسندگان
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