کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5273012 1385479 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis
چکیده انگلیسی

To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 45, 3 November 2008, Pages 6429-6432
نویسندگان
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