کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5273165 1385483 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Concise synthesis of an arabinofuranose hexasaccharide present in the cell wall of Mycobacterium tuberculosis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Concise synthesis of an arabinofuranose hexasaccharide present in the cell wall of Mycobacterium tuberculosis
چکیده انگلیسی

Mycobacterium cell wall consists of three major polysaccharide portions and arabinofuranose (Araf) is present in two of the major portions, arabinogalactan (AG) and lipoarabinomannan (LAM). A peculiar Araf hexasaccharide possessing two β-linked Araf units are present in both AG and LAM polysaccharides. Herein, we report an efficient and concise synthesis of this Araf hexasaccharide using single starting 3,5-TIPDS protected Araf thioglycoside precursor. Double β-glycosylation was achieved using strained cyclic 2-p-methoxybenzyl-3,5-TIPDS Araf thioglycoside donor.

An efficient and concise synthesis of Araf hexasaccharide using single starting 3,5-TIPDS protected Araf thioglycoside precursor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 19, 9 May 2012, Pages 2461-2464
نویسندگان
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