Asymmetric induction in domino Heck-aza-Michael reactions

Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81%) with moderate to high diastereoselectivity (up to 92% de).