Bismuth nitrate-catalyzed multicomponent reaction for efficient and one-pot synthesis of densely functionalized piperidine scaffolds at room temperature

A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot synthesis of densely functionalized piperidine scaffolds has been developed based on a low-cost and environmentally benign Bi(NO3)3·5H2O catalyst via tandem reactions of 1,3-dicarbonyl compounds, aromatic aldehydes, and amines in ethanol at room temperature. Mild reaction conditions, good yields, high diastereoselectivity, operational simplicity, and the absence of tedious separation procedures, clean reaction profiles, high atom-economy, inexpensive starting materials, and environmentally benign catalyst are the key advantages of the present protocol.