کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5274265 | 1385507 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A greener synthesis of 1,8-dioxo-octahydroxanthene derivatives under ultrasound A greener synthesis of 1,8-dioxo-octahydroxanthene derivatives under ultrasound](/preview/png/5274265.png)
The ceric ammonium nitrate (CAN) has been identified as an efficient and eco-friendly catalyst for the one pot and virtually three-component reaction of 5,5-dimethyl-1,3-cyclohexanedione with various aldehydes in 2-propanol. Under ultrasound irradiation, the reaction proceeded smoothly at a faster rate at 50 °C affording a variety of 9-alkyl/aryl/heteroaryl substituted 3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-diones in good to excellent yields. A probable mechanism for this CAN-mediated synthesis of 1,8-dioxo-octahydroxanthene derivatives is presented. Overall, the methodology provides advantages such as low cost, high yields of products and simple operational procedures and is free from the use of harmful chlorinated solvents.
Journal: Tetrahedron Letters - Volume 53, Issue 51, 19 December 2012, Pages 6923-6926