کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5274283 1385507 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator
چکیده انگلیسی

The total synthesis of Resolvin D1, a potent endogenous anti-inflammatory lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C7, C8 and C17 were obtained via a chiral pool strategy from 2-deoxy-d-ribose. Wittig reactions followed by a modified Pd0/CuI Sonogashira coupling and Zn(Cu/Ag) cis-reduction completed the total synthesis of Resolvin D1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 51, 19 December 2012, Pages 6990-6994
نویسندگان
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