On the regiochemistry of Mitsunobu alkylations of hydrazine derivatives

That differentially protected hydrazines of the type TsNHNHCOR3 undergo regiospecific Mitsunobu reactions with a variety of alcohols, R1R2CHOH in a generalised manner, to give good to excellent yields of the mono-adducts Ts(R1R2CH)NNHCOR3, has been proven by X-ray crystallographic analysis.