کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5274448 | 1385511 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An efficient synthesis of fused morpholine oxadiazoline core structures was accomplished in an effort to identify optimum gamma secretase modulator leads in the treatment of Alzheimer's disease. Reaction pathways were proposed for the key intramolecular cyclization reaction, and chemistry was designed to probe these hypotheses. A highly diastereoselective synthesis of potent GSM 27 was achieved. To further improve the synthesis, a second route was developed which successfully addressed the formation of a fused seven-member ring by-product, and provided opportunities to accelerate future SAR studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 47, 21 November 2012, Pages 6451-6455
Journal: Tetrahedron Letters - Volume 53, Issue 47, 21 November 2012, Pages 6451-6455
نویسندگان
Xianhai Huang, Dmitri Pissarnitski, Hongmei Li, Theodros Asberom, Hubert Josien, Xiaohong Zhu, Monica Vicarel, Zhiqiang Zhao, Murali Rajagopalan, Anandan Palani, Robert Aslanian, Zhaoning Zhu, William Greenlee, Alexei Buevich,