کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5274847 | 1385520 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
First synthesis of natural phosphatidyl-β-d-glucoside
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Herein, we report the chemical synthesis of naturally occurring mammalian phosphatidyl-β-d-glucoside (PtdGlc), in order to confirm the proposed structure and to clarify its stereochemistry. We designed a convergent synthetic strategy, suitable to prepare sensitive PtdGlc derivatives. As an initial demonstration of our strategy, we successfully prepared both PtdGlc diastereomers as well as its sensitive arachidonyl analogue. The presence of both diastereomers in the natural sample was confirmed.
Chemical syntheses of phosphatidylglucoside (PtdGlc) and its derivatives were achieved via an H-phosphonate intermediate. The proposed structure of natural PtdGlc was confirmed. The suggested presence of sn-2-epimer in natural sample was validated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 22, 26 May 2008, Pages 3562-3566
Journal: Tetrahedron Letters - Volume 49, Issue 22, 26 May 2008, Pages 3562-3566
نویسندگان
Peter Greimel, Yukishige Ito,