کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5274905 1385521 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient sequential one-pot base mediated C-O and Pd-mediated C-C bond formation: synthesis of functionalized cinnamates and isochromenes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient sequential one-pot base mediated C-O and Pd-mediated C-C bond formation: synthesis of functionalized cinnamates and isochromenes
چکیده انگلیسی

An efficient sequential one-pot intermolecular oxy-Michael addition and intermolecular Heck coupling for the synthesis of functionalized cinnamates is presented. Bulky tert-butyl acrylate was identified as a more suitable Michael acceptor for initial oxy-Michael addition, as it precludes the formation of undesired cross condensed ester. Most importantly, the present method was further divergently extended to the successful synthesis of isochromenes via a sequential one-pot O-allylation and subsequent intramolecular Heck cyclization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 42, 17 October 2012, Pages 5635-5640
نویسندگان
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