Asymmetric lithiation of 2-alkynyl aryl sulfides-Enantio- and diastereoselective formation of allenyl aryl sulfides and their application in nickel-catalyzed cross-coupling reactions

Allenyl aryl sulfides are synthesized enantio- and diastereoselectively by asymmetric lithiation of 2-alkynyl aryl sulfides. Subsequent nickel-catalyzed coupling reactions afforded threefold carbon-substituted allenes.