The biosynthesis of sorbicillinoids in Trichoderma sp. USF-2690: prospect for the existence of a common precursor to sorbicillinol and 5-epihydroxyvertinolide, a new sorbicillinoid member

Biosynthetic feeding studies of [1-13C], [2-13C], and [1,2-13C2]-labeled sodium acetates into 5-epihydroxyvertinolide, a new sorbicillinoid, gives an incorporation pattern that proves the γ-lactone ring formation associated with a ring cleavage reaction of the precursor, a potential intermediate of sorbicillinol biosynthesis.