Synthesis of prolinal dithioacetals as catalysts for the highly stereoselective Michael addition of ketones and aldehydes to β-nitrostyrenes

Catalytic highly enantioselective (up to >99% ee) and diastereoselective (up to 99% de) direct Michael addition of ketones and aldehydes to β-nitrostyrenes have been achieved with readily accessible and highly tunable prolinal dithioacetal catalysts.

High enantioselectivity and diastereoselectivity has been achieved in the direct Michael addition with readily tunable prolinal dithioacetal catalysts.