Iodine-catalyzed allylation and propargylation of indoles with allylic and propargylic acetates

A mild and efficient allylation/propargylation of indoles has been developed with high regioselectivity and excellent yields. In the presence of catalytic molecular iodine, various indoles could react with allylic/propargylic acetates smoothly at room temperature to exclusively provide C-3 alkylated products.

A mild and efficient allylation/propargylation of indoles has been developed with high regioselectivities and excellent yields. In the presence of catalytic molecular iodine, various indoles could smoothly react with allylic/propargylic acetates at room temperature to exclusively provide C-3 alkylated products.