کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5276875 1385567 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An efficient one-pot, two-step synthesis of 4-substituted 1-heteroarylpiperazines under microwave irradiation conditions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
An efficient one-pot, two-step synthesis of 4-substituted 1-heteroarylpiperazines under microwave irradiation conditions
چکیده انگلیسی
A highly efficient one-pot, two-step microwave procedure has been developed for the synthesis of 4-substituted 1-heteroarylpiperazines. Microwave heating of heteroaryl chlorides with 1,4-diazabicyclo[2.2.2]octane (DABCO) at 160 °C for 15 min yielded 1-heteroaryl-4-(2-chloroethyl)piperazines, which could be further reacted with various nucleophiles, again under microwave irradiation conditions, to give an array of 4-substituted 1-heteroarylpiperazines in good to excellent yields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 17, 23 April 2007, Pages 3043-3046
نویسندگان
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