Thiophenol mediated radical cyclization: an expedient approach to 2H-pyrrolo[3,2-d]pyrimidines (9-deazaxanthine analogs)

A new efficient route for the synthesis of substituted 2H-pyrrolopyrimidines (9-deazaxanthine analogs) via thiophenol mediated radical cyclization has been achieved. The stereochemistry of the newly synthesised compounds has been settled from NOE data.