کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5279213 1385620 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of tetrazole analogues of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides
چکیده انگلیسی

An efficient synthesis of tetrazole analogues of amino acids starting from Nα-Fmoc amino acid in a three-step protocol is reported. The free amino tetrazoles were obtained in good yields and with excellent purity after removal of the Fmoc group. The synthesis of analogues of aspartic and glutamic acids in which the 5-tetrazolyl moiety is inserted at the β/γ carboxyl group starting from Fmoc-Asn and Fmoc-Gln and the incorporation of these tetrazoles into peptides are also described.

Tetrazole analogues of amino acids have been prepared employing Fmoc chemistry and [2+3] cycloaddition. Tetrazole rings have also been incorporated into the side chains of Asp/Glu via a similar procedure and utilized for peptide synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 48, Issue 39, 24 September 2007, Pages 7038-7041
نویسندگان
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