One-pot syntheses of 1,2,3-triazoles containing a pentafluorosulfanylalkyl group via click chemistry

1,4-Disubstituted 1,2,3-triazoles containing a pentafluorosulfanylalkyl group were synthesized in good to excellent yields (57-91%) by the click cycloadditions of in situ generated SF5-alkyl azides with aromatic and aliphatic alkynes. Nucleophilic substitution of the SF5 group was observed for the first time in a bench-top reaction.