A practical highly selective oxybromination of phenols with dioxygen

A simple, low cost and highly selective method for the synthesis of mono-bromophenols from phenol and electron-rich phenolic compounds has been developed. Bromide ions are used as halogenating agents, dioxygen as a final oxidant, and Cu(OAc)2 as a catalyst.

A simple, low cost, and highly selective method for the synthesis of mono-bromophenols has been developed. Bromide ions are used as halogenating agents, dioxygen as a final oxidant, and Cu(OAc)2 as a catalyst.