کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5280027 1385638 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of phosphatase-resistant analogues of phytic acid (InsP6)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of phosphatase-resistant analogues of phytic acid (InsP6)
چکیده انگلیسی

Phytic acid is enzymatically catabolized to numerous inositol polyphosphates and subsequently to myo-inositol and inorganic phosphate. These conversions are important in energy metabolism, metabolic regulation, and signal transduction pathways. A concise synthesis of phosphatase-resistant analogues of phytic acid (InsP6) is described in which the P-1 phosphate has been replaced by phosphorothioate, phosphoroselenate, or methylphosphonate moieties. In addition, a new synthesis of P-1 tethered aminoalkyl InsP6 and the corresponding affinity resin are described.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 46, Issue 48, 28 November 2005, Pages 8311-8314
نویسندگان
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