Facile synthesis of α-functionalized vinyl sulfides bearing β-trifluoromethyl group: a highly potential CF3-containing building blocks

The β-(trifluoromethyl)vinylsulfides on treatment with n-BuLi/TMEDA were readily lithiated at α-position of the sulfanyl group, and the generated α-lithiovinylsulfides were trapped with a variety of electrophiles to give the corresponding β-trifluoromethyl-α-functionalized vinylsulfides in good to high yields.