کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5281019 | 1385660 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thioester-assisted α-sialylation reaction
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
α-Selective sialylation reactions were carried out using novel sialic acid building blocks that possess a thioester auxiliary. In contrast to other arylthio- and benzylthioester derivatives, sialyl phosphite 1a (with the phenylthioester moiety) was employed as the α-selective building block, and was reacted with various primary alcohols, including the C6-OH group of galactose and glucose, with moderate to excellent α-selectivities. For C3-OH of the galactose, 4,6-di-O-benzylgalactal afforded desired α-linkage with excellent selectivity.
α-Selective sialylation reactions using novel sialic acid building blocks carrying thioester type auxillary was described.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 34, 18 August 2008, Pages 5111-5114
Journal: Tetrahedron Letters - Volume 49, Issue 34, 18 August 2008, Pages 5111-5114
نویسندگان
Shinya Hanashima, Shoji Akai, Ken-ichi Sato,