کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5282796 | 1385700 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of 2â²-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of 2â²-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones Synthesis of 2â²-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones](/preview/png/5282796.png)
چکیده انگلیسی
Oligodeoxyribonucleotides that contain a novel nucleoside, 2â²-O-(2-hydrazinoethyl)uridine, were synthesised by NaBH3CN reduction of hydrazones formed from 2â²-O-(2-oxoethyl)oligonucleotides with FmocNHNH2, followed by concd aq NH3 deprotection. The 2â²-hydrazine oligonucleotides obtained were then used to synthesise a number of conjugates with aldehydes via hydrazone formation and with1,3-diketones via pyrazole formation. The method was shown to be applicable for the preparation of oligonucleotide-peptide conjugates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 31, 31 July 2006, Pages 5515-5518
Journal: Tetrahedron Letters - Volume 47, Issue 31, 31 July 2006, Pages 5515-5518
نویسندگان
Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya, Dmitry A. Stetsenko,