Synthesis of 1,2-annulated adamantane heterocycles: structural determination studies of a bioactive cyclic sulfite

The synthesis, conformational assignment and biological analysis of novel 1,2-annulated adamantane cyclic sulfite 5 are undertaken and the susceptibility of oxetane 4 to nucleophilic attack and ring opening, which leads to useful precursors for the synthesis of bioactive adamantane derivatives, is examined.