کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5283330 | 1385713 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imine allylation using 2-alkoxycarbonyl allylboronates as an expedient three-component reaction to polysubstituted α-exo-methylene-γ-lactams
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
α-exo-Methylene-γ-lactams are key structural units in a wide variety of biologically active natural products. A concise route to the formation of polysubstituted α-exo-methylene-γ-lactams is described. In this three-component reaction, an imine is formed from an aldehyde and ammonia in situ, and is subsequently allylated through the use of a 2-alkoxycarbonyl allylboronate. Due to the ester functionality, the addition intermediate subsequently undergoes in situ cyclization to form the observed α-exo-methylene-γ-lactam products. This route allows access to highly substituted α-exo-methylene-γ-lactams in moderate to excellent yields.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 49, 1 December 2008, Pages 6995-6998
Journal: Tetrahedron Letters - Volume 49, Issue 49, 1 December 2008, Pages 6995-6998
نویسندگان
Tim G. Elford, Dennis G. Hall,