3-(4-Hydroxymethylphenylsulfanyl)propanoic acid (HMPPA) as a new safety catch linker in solid phase peptide synthesis

A new safety catch linker is described for use in solid phase peptide synthesis. The linker is readily synthesized from commercially available chemicals and, when attached to a solid support, is very stable towards strong acid treatment. Final resin cleavage is performed by reductive acidolysis.