کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5289637 | 1385860 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8â11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 47, Issue 29, 17 July 2006, Pages 5187-5190
Journal: Tetrahedron Letters - Volume 47, Issue 29, 17 July 2006, Pages 5187-5190
نویسندگان
Li-Mei Li, Guo-You Li, Wei-Lie Xiao, Yan Zhou, Sheng-Hong Li, Sheng-Xiong Huang, Quan-Bin Han, Li-Sheng Ding, Li-Guang Lou, Han-Dong Sun,