Improved functionalization of electrospun PLLA/gelatin scaffold by alternate soaking method for bone tissue engineering

► Hydroxyapatite (HA) worked as a binder of gelatin in composite scaffold. ► Osteoblasts activity was found to be highest on PLLA/Gel/HA at day 7 compared to all other scaffolds. ► PLLA/Gel and PLLA/Gel/HA exhibited minimum terminal complement complex concentration. ► PLLA/Gel/HA scaffold displayed better osteostimulation with lesser immune response.