کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5370927 1503919 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of terpenes on fluidity and lipid extraction in phospholipid membranes
ترجمه فارسی عنوان
اثر ترپن ها بر روی سیالیت و استخراج لیپید در غشای فسفولیپید
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی


- Terpenes increase the overall lipid dynamics in phospholipid membranes.
- Lipid extraction from a model membrane by terpenes is characterized.
- The thermodynamic profile associated with the terpene-membrane interactions is presented.

Electron paramagnetic resonance (EPR) spectroscopy was used in a detailed study of the interactions of several terpenes with DPPC membranes. EPR spectra of a spin-label lipid allowed the identification of two well-resolved spectral components at temperatures below and above the main phase transition of the lipid bilayer. Terpenes caused only slight mobility increases in each of these spectral components; however, they substantially increased the population of the more mobile component. In addition, the terpenes reduced the temperature of the main phase transition by more than 8 °C and caused the extraction of the spin-labeled lipid. Nerolidol, which had the highest octanol-water partition coefficient, generated the highest amount of spin label extraction. Acting as spacers, terpenes should cause major reorganization in cell membranes, leading to an increase in the overall molecular dynamics of the membrane. At higher concentrations, terpenes may cause lipid extraction and thus leakage of the cytoplasmic content.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 198, March 2015, Pages 45-54
نویسندگان
, ,