کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5371886 1503967 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Raman spectroscopic investigation on the interaction of malignanthepatocytes with doxorubicin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Raman spectroscopic investigation on the interaction of malignanthepatocytes with doxorubicin
چکیده انگلیسی

Raman spectroscopy has proven to be a very powerful technique and is currently experiencing a renaissance. In this paper, it is used to explore the interaction between doxorubicin and malignant hepatocytes in vitro. For the addition of doxorubicin, the band intensity at 1609 cm− 1, mainly assigned to CC in-plane bending mode of phenylalanine and/or tyrosine residues, increases significantly, and the intensities of the bands at 1585 and 1313 cm− 1, mainly due to the guanine bases, decrease greatly. In addition, Raman spectra are investigated at different doxorubicin concentrations, and the mean areas ratios of the band at 1450 to that at 1003 cm− 1, A1450/A1003, fluctuate according to the doxorubicin concentration increasing, which suggests that doxorubicin affects the relative content of lipid in cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 140, Issues 1–3, March 2009, Pages 57-61
نویسندگان
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