کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5372126 1503979 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cooperative equilibrium curves generated by ordered ligand binding to multi-site molecules
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Cooperative equilibrium curves generated by ordered ligand binding to multi-site molecules
چکیده انگلیسی

The sigmoid shape of equilibrium curves in normal axes and Hill coefficients higher than unity, are indexes of cooperativity or homotropic allostery where the affinity for the ligand increases as saturation progresses. The mathematical transformation of the Adair scheme of equilibria in the Hill plot, reveals that sigmoid binding curves can also be generated by ordered ligand binding to a receptor with multiple binding sites of identical microscopic association constants. This mechanism only based on the law of mass action, could participate to some extent to certain cooperative effects observed in non-biological systems and perhaps in the physiological binding of oxygen to heme proteins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 129, Issues 2–3, September 2007, Pages 284-288
نویسندگان
,