کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5372126 | 1503979 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cooperative equilibrium curves generated by ordered ligand binding to multi-site molecules
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
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چکیده انگلیسی
The sigmoid shape of equilibrium curves in normal axes and Hill coefficients higher than unity, are indexes of cooperativity or homotropic allostery where the affinity for the ligand increases as saturation progresses. The mathematical transformation of the Adair scheme of equilibria in the Hill plot, reveals that sigmoid binding curves can also be generated by ordered ligand binding to a receptor with multiple binding sites of identical microscopic association constants. This mechanism only based on the law of mass action, could participate to some extent to certain cooperative effects observed in non-biological systems and perhaps in the physiological binding of oxygen to heme proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volume 129, Issues 2â3, September 2007, Pages 284-288
Journal: Biophysical Chemistry - Volume 129, Issues 2â3, September 2007, Pages 284-288
نویسندگان
Denis Michel,