کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5372284 | 1503983 | 2007 | 8 صفحه PDF | دانلود رایگان |
The physico-chemical properties of β-lactosyl-closo-orthocarborane in water solution were investigated by multinuclear NMR, 13C NMR relaxation, and ab-initio calculations. This molecule represents a potentially selective boron carrier in Boron Neutron Cancer Therapy (BNCT) and exhibits amphiphilic characteristics. Its structural and dynamic features were studied comparing NMR data acquired in both aggregating and non-aggregating conditions. Aggregates are characterized by rapid exchange with the bulk and by high sensitivity to temperature conditions. An unusually stable intra-molecular CHO hydrogen bond was found to persist in water solution both for the free molecules and after aggregate formation. At the same time, inter-molecular specific CHO interactions do not seem effective in the aggregate formation process, which appears to take place only on non-specific hydrophobic basis.
Journal: Biophysical Chemistry - Volume 125, Issues 2â3, February 2007, Pages 320-327