کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5372514 | 1388886 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A simple tool to explore the distance distribution of correlated mutations in proteins A simple tool to explore the distance distribution of correlated mutations in proteins](/preview/png/5372514.png)
The analysis of correlated mutations in protein sequence alignments is of considerable interest, since it may provide useful energetic and even structural information (ideally, residue contacts). However, a number of recent experimental studies support the existence of long-distance communication in proteins, a fact that may lead to correlation between distant residues. We introduce in this work a simple statistical procedure to describe the relation structure-alignments on the basis of the residue-residue distance dependence of the number of residue couples over given thresholds of a correlation measure (such as a covariance value). This procedure may lead to clear pictures of the distance distribution of correlated mutations and may provide a simple but efficient tool to explore the different structural features that are reflected in the sequence alignments.
Journal: Biophysical Chemistry - Volume 119, Issue 3, 1 February 2006, Pages 240-246