کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5398929 1505899 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of antihypertensive drug amiloride with metal ions in micellar medium using fluorescence spectroscopy
ترجمه فارسی عنوان
تعامل آمیلورید داروهای ضد فشار خون با یونهای فلزی در محیط میکروسلی با استفاده از طیف سنجی فلورسانس
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی
Steady state and life time fluorescence spectroscopy have been employed to study the interaction of antihypertensive drug amiloride with biologically important metal ions i.e. Cu2+, Fe2+, Ni2+ and Zn2+ in various micellar media (anionic SDS (sodium dodecyl sulfate), nonionic TX-100 (triton X-100) and cationic CTAB (cetyl trimethyl ammonium bromide)). It was observed that fluorescence properties of drug remain unaltered in the absence of micellar media with increasing concentration of metal ions. However, addition of Cu2+, Fe2+ and Ni2+ caused fluorescence quenching of amiloride in the presence of anionic micelle, SDS. Binding of drug with metal ions at the charged micellar interface could be the possible reason for this pH-dependent metal-mediated fluorescence quenching. There were no remarkable changes observed due to metal ions addition when drug was present in cationic and nonionic micellar medium. The binding constant and bimolecular quenching constant were evaluated and compared for the drug-metal complexes using Stern-Volmer equation and fluorescence lifetime values.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Luminescence - Volume 161, May 2015, Pages 87-94
نویسندگان
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