An interaction of the functionalized closo-borates with albumins: The protein fluorescence quenching and calorimetry study

The complex formation between albumin and the closo-borate molecules has been confirmed by isothermal titration calorimetry (ITC). The compound (K2[B10H10]) and its arylamine derivative both interact with HSA, have close values of Ka (1.4 and 1.2×103 M−1 respectively) and Gibbs energy (−17.9 and −17.5 kJ/mol respectively). However, the arylamine derivative forms complex with the higher guest/host binding ratio (4:1) comparing to the parent closo-borate (2:1).