کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
540003 | 1450370 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Wet sample confinement by superhydrophobic patterned surfaces for combined X-ray fluorescence and X-ray phase contrast imaging Wet sample confinement by superhydrophobic patterned surfaces for combined X-ray fluorescence and X-ray phase contrast imaging](/preview/png/540003.png)
In this work we propose a wet sample handling technique which enables the simultaneous collection of X-ray fluorescence (XRF) spectra and X-ray phase contrast imaging (XPCI) using a few microliters drop confined on a superhydrophobic surface. To this purpose, we fabricated and tested a superhydrophobic patterned surface entailing an hydrophilic region which leads to pinning of the drop, enabling X-ray beam effortless alignment and measuring in liquid phase. Our technique allows to acquire capillary-free XRF spectra, resulting in a significant fluorescence detection gain, which is particularly interesting for light elements. Simultaneous XPCI provides sample geometry assuring a fine control of the experimental conditions and allowing real time monitoring of the drop during measurements. As an additional advantage – after solvent evaporation – the solute is deposited on a precise spot, greatly increasing its concentration allowing further measurements, such as X-ray microanalysis and X-ray diffraction.These results could have potential applications in the study of blood proteins, such as ferritin and low density lipoprotein, which are usually available in very limited quantity.
Figure optionsDownload as PowerPoint slideHighlights
► A superhydrophobic structure has been realized for wet sample handling in X-ray measurements.
► First measuring tests has been carried on for X-ray fluorescence, phase contrast imaging, and X-ray diffraction.
► Test measurements on ferritin protein sample has been done.
Journal: Microelectronic Engineering - Volume 111, November 2013, Pages 304–309