کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5400102 | 1505918 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular displacement of warfarin from human serum albumin by flavonoid aglycones
ترجمه فارسی عنوان
جابجایی مولکولی وارفارین از آلبومین سرم انسان توسط آگیلکون فلاونوئید
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کلمات کلیدی
وارفارین، آگلیکون فلاونوئید، آلبومین سرم انسان، طیف سنجی فلورسانس، جابجایی مولکولی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
The well-known 4-hydroxycoumarin derivative warfarin is a widespread anticoagulant drug. Besides its strong albumin binding property warfarin has a narrow therapeutic window. Therefore, a few percent of displacement from albumin can result in serious biological consequences. The flavonoid molecular group also shows very strong plasma albumin binding characteristics occupying the same binding site. It is plausible to hypothesize that flavonoid aglycones may be able to displace warfarin from human serum albumin (HSA). In our study the competing activities of different flavone (acacetin, apigenin, chrysin, luteolin), flavonol (galangin, quercetin) and flavanone (hesperetin, naringenin) aglycones were investigated using fluorescence spectroscopy. Our results represent that flavonoids are able to displace warfarin from the surface of HSA. On the other hand, when comparing flavone or flavonol groups to flavanones the latter group seems to be much weaker competitor. These observations were also supported by calculation of stability constants. Our investigations strongly suggest that we should reckon with the described molecular displacement. However, further in vivo studies are needed to support the findings of our model system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Luminescence - Volume 142, October 2013, Pages 122-127
Journal: Journal of Luminescence - Volume 142, October 2013, Pages 122-127
نویسندگان
Miklós Poór, Yin Li, Sándor Kunsági-Máté, József Petrik, Sanda Vladimir-KneževiÄ, Tamás KÅszegi,