Synthesis and properties of an efficient tumor cells-interacting fluorescent probe derived from rhodamine B

A novel fluorescent compound (T) was synthesized based on the structure of rhodamine B. The main advantage of the new derivative is the selective detection of tumor cells. In the present work, the fluorescent properties of the probe were measured and its inhibition on three kinds of tumor cell lines (SMMC-7721, A431 and LoVo cells) was tested. Different concentrations of T were added into the A431 cells for fluorescence imaging analysis under normal condition. The results suggested that the new probe has not only fluorescence but also inhibitory effects on tumor cells to a certain extent, which indicates its further use on tracer analysis.