The influence of β-cyclodextrin on the interaction of hesperetin and its bismuth (III) complex with calf thymus DNA

► Hesperetin forms a 1:2 complex and hesperetin-Bi (III) forms a 1:1 with β-CD. ► The effect of β-CD on ctDNA interacted hesperetin/hesperetin-Bi (III) is reported. ► Hesperetin and its β-CD complex bind more strongly with ctDNA than Hes-Bi (III) complex. ► 1:1 stoichiometry is observed for Hes/Bhes with ctDNA in water and in β-CD.