Spectrofluorimetric study on the inclusion behavior of p-sulfonated calix [6] arene with cetyltrimethylammonium bromide and analytical application

The characteristics of host-guest complexation between p-sulfonated calix [G. Arena, S. Gentile, F. G. Gulino, D. Sciotto, C. Sgarlata, Tetrahedron Lett. 45 (2004) 7091] arene (SC6A) and cationic surfactant cetyltrimethylammonium bromide (CTAB) were studied by fluorescence spectrometry. A 1:1 stoichiometry for the complexation was established and the complex constant was also calculated by a deduced equation. It was found the fluorescence of the complex could be remarkably quenched by an appropriate amount of ceftriaxone sodium (CTRX). Based on the results, a novel spectrofluorimetric method for determination of CTRX was developed with a linear range of 9.2×10−7-8.5×10−5 mol L−1 and a detection of 3.5×10−7 mol L−1. The proposed method was used to determine CTRX in their commercial preparations with satisfactory results. Moreover, the probable interaction mechanisms of the systems were also discussed.