کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5408642 | 1506538 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, Characterization and Antimicrobial properties of Methylbenzyl and Nitrobenzyl containing Imidazolium-based Silver N-Heterocyclic Carbenes
ترجمه فارسی عنوان
سنتز، خصوصیات و خواص ضد میکروبی متیل بنزیل و نیتروبنزیل حاوی نانوذرات هیدروکلریک کربن نقره ای مبتنی بر اتیازولیم
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کلمات کلیدی
ضد میکروبی تحریف دیوار سلولی، حداقل غلظت مهارکننده، نان هیدروکسیل کربن، نقره،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
A series of imidazolium-based novel ionic liquids (ILs) containing methylbenzyl and nitrobenzyl substituents were prepared and further converted to neutral as well as ionic silver complexes. The ILs and their Ag-NHCs (N-Heterocyclic Carbenes) were successfully characterized by NMR, FT-IR, and EI-MS studies. The ILs and Ag-NHCs were screened for antimicrobial activity based on the zone of inhibition, Minimum Inhibitory Concentration (MIC) determination, and stability studies against Salmonella enterica and Staphylococcus aureus. The neutral complex NS-32 ((1-((2â²-cyano-[1,1â²-biphenyl]-4-yl)methyl)-3-(4-nitrobenzyl)-2,3-dihydroimidazol-2-yl)silver bromide) was the most active with MIC of 25 μM and showed efficient growth inhibition of bacterial pathogens even up to 21 d. The complex NS-32 was further monitored for cell wall disruption by scanning electron microscopy (SEM). The photomicrographs of bacterial cells obtained by SEM after treatment of NS-32 with S. enterica and S. aureus showed rupture of a cell wall, thus proving it to be the site of action and ultimately having inhibitory effects on the microbial cell growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Liquids - Volume 233, May 2017, Pages 270-277
Journal: Journal of Molecular Liquids - Volume 233, May 2017, Pages 270-277
نویسندگان
Sainath Aher, Anamika Das, Prashant Muskawar, Jabez Osborne, Pundlik Bhagat,